Новое исследование с использованием ABI-system 100 :Доклинические ортостатические аномалии могут предсказать раннее увеличение сосудистой жесткости в разных возрастных группах:пилотное исследование Preclinical Orthostatic Abnormalities May Predict Early
Increase in Vascular Stiffness in Different Age Groups:
A Pilot StudyVictor N. Dorogovtsev 1,* , Dmitry S. Yankevich 1, Andrey E. Gaydashev 2, Andrey V. Martyushev-Poklad 1 ,
Julia A. Podolskaya 1, Ilya V. Borisov 1 and Andrey V. Grechko 1
1 Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia;
dyankevich@fnkcrr.ru (D.S.Y.);
amp@fnkcrr.ru (A.V.M.-P.);
upodolskaya@fnkcrr.ru (J.A.P.);
realzel@gmail.com (I.V.B.);
noo@fnkcrr.ru (A.V.G.)
2 Problem Scientific Research Laboratory, Smolensk State Medical University, 214019 Smolensk, Russia;
pnil-kardio@yandex.ru* Correspondence:
dorogovtsev.victor3@gmail.comAbstract: Clinical orthostatic hypotension (OH) and hypertension (OHT) are risk factors for arterial
hypertension (AH) and cardiovascular diseases (CVD) and are associated with increased vascular
stiffness. Preclinical OH and OHT are poorly understood. The main objective was to investigate
preclinical orthostatic abnormalities and their association with increased vascular stiffness in different
age groups of adults. A specially designed head-up tilt test standardized for hydrostatic column
height was used to detect them. Three age groups of clinically healthy subjects were examined. In the
group of young adults up to 30 years old, a significant predominance of orthostatic normotension
(ONT) and an insignificant number of subjects with preclinical OH and OHT were found. In the
age group over 45 years, compared to the group under 30 years, there was a twofold decrease in
the proportion of individuals with ONT and a significant increase with preclinical OH and OHT.
In all age groups, there was a significant orthostatic increase in vascular stiffness (as measured by
the brachial–ankle pulse wave velocity (baPWV), which was recovered to the baseline level when
returning to the supine position. Overall, subjects with preclinical OH and OHT had significantly
higher baPWV values compared to those with ONT (p = 0.001 and p = 0.002, respectively), with all
subjects having vascular stiffness values within normal age-related values.
Keywords: head-up tilt test; arterial hypertension; blood pressure; preclinical orthostatic hypotension;
preclinical orthostatic hypertension; pulse wave velocity; vascular stiffness; vascular aging
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Тема: ABI-system 100 (Прочитано 45476 раз)